Cardiac muscle mechanics: Sarcomere length matters
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چکیده
منابع مشابه
Cooperative activation in cardiac muscle: impact of sarcomere length.
This study was undertaken to determine the impact of sarcomere length (SL) on the level of cooperative activation of the cardiac myofilament at physiological [Mg2+]. Active force development was measured in skinned rat cardiac trabeculae as a function of free [Ca2+] at five SLs (1.85-2.25 microm; 1 mM free [Mg2+]; 15 degrees C). Only muscle preparations with minimal force rundown during the ent...
متن کاملIntraoperative single-site sarcomere length measurement accurately reflects whole-muscle sarcomere length in the rabbit.
PURPOSE To compare single-site intraoperative sarcomere length values with sarcomere lengths measured from systematic sampling of the entire transferred muscle. METHODS The tendon of the rabbit second toe extensor muscle was transposed to the ankle extensor retinaculum under levels of stretch over the sarcomere length range of about 2.5 microm to about 4.0 microm. Intraoperative sarcomere len...
متن کاملMechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width.
A ventricular myocyte experiences changes in length and load during every beat of the heart and has the ability to remodel cell shape to maintain cardiac performance. Specifically, myocytes elongate in response to increased diastolic strain by adding sarcomeres in series, and they thicken in response to continued systolic stress by adding filaments in parallel. Myocytes do this while still keep...
متن کاملThe Sarcomere Length-Tension Relation in Skeletal Muscle
I N T R O D U C T I O N T e n s i o n d e v e l o p m e n t d u r i n g an i s o m e t r i c t e t a n u s in ske le ta l musc le occu r s in t h r e e d i s t inc t phases : t en s ion ini t ia l ly r ises r a p i d l y , t h e n c l imbs m o r e s lowly, a n d f ina l ly r e a c h e s a p l a t e a u which lasts m a n y s e c o n d s . T h i s t i m e c o u r s e is o b s e r v e d d u r i n ...
متن کاملSarcomere length influences postmortem proteolysis of excised bovine semitendinosus muscle.
The interaction between sarcomere length and postmortem proteolysis as related to meat tenderness is not clear. The extent of thick and thin filament overlap alters actomyosin binding and may alter substrate availability during aging-induced tenderization. The objective of this study was to determine the influence of sarcomere length on proteolytic degradation in beef. Strips from bovine semite...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2016
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2015.12.006